Mayamycin, a Cytotoxic Polyketide from aStreptomycesStrain Isolated from the Marine SpongeHalichondria panicea.

Schneemann, Imke, Kajahn, Inga, Ohlendorf, Birgit, Zinecker, Heidi, Erhard, Arlette, Nagel, Kerstin, Wiese, Jutta and Imhoff, Johannes F. (2010) Mayamycin, a Cytotoxic Polyketide from aStreptomycesStrain Isolated from the Marine SpongeHalichondria panicea. Journal of Natural Products, 73 (7). pp. 1309-1312. DOI 10.1021/np100135b.

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Abstract

A new benz[a]anthracene derivative called mayamycin (1) was identified in cultures of Streptomyces sp. strain HB202, which was isolated from the marine sponge Halichondria panicea and selected because of its profound antibiotic activity. The ability to produce aromatic polyketides was indicated by genetic analyses, demonstrating the presence of a type II polyketide synthase. The production of mayamycin (1) was induced by variation of the culture conditions. The structure of 1 was elucidated by HPLC-UV/MS and NMR spectroscopy. Mayamycin (1) exhibited potent cytotoxic activity against eight human cancer cell lines and showed activity against several bacteria including antibiotic-resistant strains.

Document Type: Article
Additional Information: WOS:000280140500021
Keywords: Microbiology; Mayamiycin; sponge; Halichondria panicea; ANTIBIOTICS; BIOSYNTHESIS; BACTERIA; GENES; ASSAY
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/np100135b
ISSN: 0163-3864
Projects: Future Ocean
Date Deposited: 26 Nov 2010 12:39
Last Modified: 04 May 2018 10:02
URI: http://oceanrep.geomar.de/id/eprint/10171

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