Nocapyrones A−D, γ-Pyrones from aNocardiopsisStrain Isolated from the Marine SpongeHalichondria panicea.

Schneemann, Imke, Ohlendorf, Birgit, Zinecker, Heidi, Nagel, Kerstin, Wiese, Jutta and Imhoff, Johannes F. (2010) Nocapyrones A−D, γ-Pyrones from aNocardiopsisStrain Isolated from the Marine SpongeHalichondria panicea. Journal of Natural Products, 73 (8). pp. 1444-1447. DOI 10.1021/np100312f.

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Abstract

Four new γ-pyrones, nocapyrones A−D (1−4), were isolated from an organic extract of the Nocardiopsis strain HB383, which was isolated from the marine sponge Halichondria panicea. These are the first γ-pyrones reported from a Nocardiopsis strain. The structures were elucidated on the basis of one- and two-dimensional NMR experiments and supported by HPLC-UV/MS and HRESIMS analyses. The biosynthesis of nocapyrone A was investigated by feeding experiments with 13C-labeled compounds. In addition, one diketopiperazine, which was only known as a synthetic compound before, was isolated. The bioactivies of 1, 2, and the diketopiperazine were evaluated in a panel of assays.

Document Type: Article
Additional Information: WOS:000281181200025
Keywords: Halichondria panicea; sponge; marine microbiology; PHYSICOCHEMICAL PROPERTIES; STREPTOMYCES; POLYKETIDE
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/np100312f
ISSN: 0163-3864
Related URLs:
Projects: Future Ocean
Date Deposited: 26 Nov 2010 12:42
Last Modified: 02 Mar 2018 13:00
URI: http://oceanrep.geomar.de/id/eprint/10172

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