Bioactive metabolites from the sponge Suberea sp.
Shaker, K. H., Zinecker, Heidi, Ghani, M. A., Imhoff, Johannes F. and Schneider, B. (2010) Bioactive metabolites from the sponge Suberea sp. Chemistry & Biodiversity, 7 (12). pp. 2880-2887. DOI 10.1002/cbdv.200900277.Full text not available from this repository. (Contact)
Two new brominated compounds, subereaphenol K (2) and 2-(3,5-dibromo-1-ethoxy-4-oxocyclohexa-2,5-dien-1-yl)acetamide (3), together with subereaphenol B (methyl 2-(2,4-dibromo-3,6-dihydroxyphenyl)acetate; 1) with a revised structure, and five dibromotyrosine-derived metabolites, 4–8, were isolated from the sponge Suberea sp. and characterized by 1D- and 2D-NMR spectroscopic and HR-MS spectrometric data. Compounds 1, 2, 6, and 8 exhibited various weak or moderate bioactivities, including antimicrobial and cytotoxic activities. Furthermore, compounds 1 and 2 inhibited human recombinant phosphodiesterase 4 (PDE4) with IC50 values of 2 μM, whereas compounds 6 and 8 were less active.
|Keywords:||Microbiology; Suberea species; Subereaphenols B and K; Metabolites; Tyrosine, dibromo-; Sponges; Antimicrobial activity; Cytotoxic activity; Inhibitors|
|Research affiliation:||OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology|
|Date Deposited:||08 Dec 2010 12:44|
|Last Modified:||23 Feb 2012 05:16|
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