Bioactivity profiling using HPLC/microtitre-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp..

Lang, Gerhard, Mitova, Maya I., Ellis, G., van der Sar, G.S., Phipps, R.K., Blunt, J.W., Cummings, N.J., Cole, A.L.J. and Munro, M.H.G. (2006) Bioactivity profiling using HPLC/microtitre-plate analysis: application to a New Zealand marine alga-derived fungus, Gliocladium sp.. Journal of Natural Products, 69 . pp. 621-624. DOI 10.1021/np0504917.

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Abstract

Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several d-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity.

Document Type: Article
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/np0504917
ISSN: 0163-3864
Date Deposited: 07 Dec 2009 13:04
Last Modified: 30 Apr 2018 12:28
URI: http://oceanrep.geomar.de/id/eprint/1065

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