Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*.

Nachtigall, Jonny, Kulik, Andreas, Helaly, Soleiman, Bull, Alan T, Goodfellow, Michael, Asenjo, Juan A, Maier, Armin, Wiese, Jutta , Imhoff, Johannes F. , Süssmuth, Roderich D and Fiedler, Hans-Peter (2011) Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*. The Journal of Antibiotics, 64 . pp. 775-780. DOI 10.1038/Ja.2011.96.

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Abstract

Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells

Document Type: Article
Additional Information: WOS:000298634600004
Keywords: Climatology; antitumor agents; atacamycins; hyper-arid soils; 22-membered macrolactone antibiotics; phosphodiesterase 4 inhibitors; Streptomyces
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1038/Ja.2011.96
ISSN: 0021-8820
Related URLs:
Projects: KIWIZ, Future Ocean
Date Deposited: 01 Dec 2011 08:50
Last Modified: 25 May 2016 09:41
URI: http://oceanrep.geomar.de/id/eprint/12682

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