Identifying core features of adaptive metabolic mechanisms for chronic heat stress attenuation contributing to systems robustness.

Gu, Jenny, Weber, Katrin, Klemp, Elisabeth, Winters, Gidon, Franssen, Susanne U., Wienpahl, Isabell, Huylmans, Ann-Kathrin, Zecher, Karsten, Reusch, Thorsten B.H. , Bornberg-Bauer, Erich and Weber, Andreas P. M. (2012) Identifying core features of adaptive metabolic mechanisms for chronic heat stress attenuation contributing to systems robustness. Integrative Biology, 4 . pp. 480-493. DOI 10.1039/c2ib00109h.

[img] Text
Gu_J_etal2012_integrBiol.pdf - Published Version
Restricted to Registered users only

Download (4Mb) | Contact

Supplementary data:

Abstract

The contribution of metabolism to heat stress may play a significant role in defining robustness and recovery of systems; either by providing the energy and metabolites required for cellular homeostasis, or through the generation of protective osmolytes. However, the mechanisms by which heat stress attenuation could be adapted through metabolic processes as a stabilizing strategy against thermal stress are still largely unclear. We address this issue through metabolomic and transcriptomic profiles for populations along a thermal cline where two seagrass species, Zostera marina and Zostera noltii, were found in close proximity. Significant changes captured by these profile comparisons could be detected, with a larger response magnitude observed in northern populations to heat stress. Sucrose, fructose, and myo-inositol were identified to be the most responsive of the 29 analyzed organic metabolites. Many key enzymes in the Calvin cycle, glycolysis and pentose phosphate pathways also showed significant differential expression. The reported comparison suggests that adaptive mechanisms are involved through metabolic pathways to dampen the impacts of heat stress, and interactions between the metabolome and proteome should be further investigated in systems biology to understand robust design features against abiotic stress.

Document Type: Article
Keywords: Evolutionary Ecology of Marine Fishes; physiology; metabolomics; transcriptomics; thermal stress
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Marine Evolutionary Ecology
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1039/c2ib00109h
ISSN: 1757-9694
Projects: Future Ocean
Date Deposited: 13 Mar 2012 07:47
Last Modified: 04 Jul 2018 06:53
URI: http://oceanrep.geomar.de/id/eprint/13986

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...