Crystalline and amorphous gold in chrysiasis.

Benn, H. P., von Gaudecker, B., Czank, M. and Loeffler, H. (1990) Crystalline and amorphous gold in chrysiasis. Arch Dermatol Res, 282 (3). pp. 172-8.

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Skin biopsy specimens from five patients (three females and two males) treated parenterally with gold were investigated using transmission electron microscopy. X-ray microanalysis and electron diffraction were used to determine the dermal heavy metal content. Additional sections were stained for light microscopic examination. The amount of elemental gold administered to the patients over a period of years to alleviate rheumatoid arthritis lay between a minimum of 4.0 g and a maximum of 10.0 g. In one and the same patient dermal histiocytic gold aggregations in sun-exposed areas of skin displayed a different pattern and divergent physiochemical states from the gold deposits in non-UV-exposed skin, where aurosome-like amorphous formations are found in the cells of the upper dermis. Additional spherical particles are associated predominantly with phagolysosomes in melanophages beneath solar-irradiated epidermis. Convergent beam electron diffraction proves the crystalline nature of the spherical auriferous deposits. The occurrence of skin rash was not related to different physicochemical states of the precious metal.

Document Type: Article
Additional Information: Benn, H P von Gaudecker, B Czank, M Loeffler, H Research Support, Non-U.S. Gov't Germany, west Archives of dermatological research Arch Dermatol Res. 1990;282(3):172-8.
Keywords: Aged Biopsy *Color Female Gold/*analysis Humans Male Microscopy, Electron Middle Aged Skin/analysis/*cytology/ultrastructure
Research affiliation: Kiel University
Refereed: No
ISSN: 0340-3696 (Print) 0340-3696 (Linking)
Date Deposited: 02 Feb 2012 07:36
Last Modified: 23 Sep 2019 18:34

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