The interpretation of lineage markers in forensic DNA testing.

Buckleton, J. S., Krawczak, M. and Weir, B. S. (2011) The interpretation of lineage markers in forensic DNA testing. Forensic Science International-Genetics, 5 (2). pp. 78-83. DOI 10.1016/j.fsigen.2011.01.010.

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Abstract

Mitochondrial DNA (mtDNA) and the non-recombining portion of the Y-chromosome are inherited matrilinealy and patrilinealy, respectively, and without recombination. Collectively they are termed 'lineage markers'. Lineage markers may be used in forensic testing of an item, such as a hair from a crime scene, against a hypothesised source, or in relationship testing. An estimate of the evidential weight of a match is usually provided by a count of the occurrence in some database of the mtDNA or Y-STR haplotype under consideration. When the factual statement of a count in the database is applied to a case, issues of relevance of the database and sampling uncertainty may arise. In this paper, we re-examine the issues of sampling uncertainty, the relevance of the database, and the combination of autosomal and lineage marker evidence. We also review the recent developments by C.H. Brenner. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Document Type: Article
Keywords: Haplotype mtDNA Y-haplotype Likelihood ratio Match probability Theta correction Population genetics match probabilities populations
Research affiliation: Kiel University
Refereed: Yes
DOI etc.: 10.1016/j.fsigen.2011.01.010
ISSN: 1872-4973
Date Deposited: 01 Nov 2012 05:00
Last Modified: 23 Jan 2013 10:01
URI: http://oceanrep.geomar.de/id/eprint/16919

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