Genetic susceptibility to infections.

Ott, S. J. and Schreiber, S. (2011) Genetic susceptibility to infections. Internist, 52 (9). 1053-+. DOI 10.1007/s00108-011-2858-8.

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Abstract

Infectious diseases are among the leading causes of morbidity and mortality worldwide. The spectrum of clinical manifestations of infections is highly variable, ranging from asymptomatic infection or mild illness to rapid progression of disease and death. Twin studies first showed an inheritable component of many infections and epidemiological and genetic studies revealed definite gene loci and polymorphisms for most of the clinically relevant infectious diseases. Reliable genetic markers which represent susceptibility or resistance to infections, prognosis of disease and response to treatment are necessary to define risk populations and to plan therapy regimens. Genetic research can also help in identifying target structures for novel therapy strategies and anitimicrobial agents. In this article the genetic background of important infections is reviewed and examples of successful exploitation of genetic findings and translation into practical medicine are given.

Document Type: Article
Keywords: Disease susceptibility Polymorphism, genetic Genetic markers Genome-wide association study World health genome-wide association mycobacterium-tuberculosis pulmonary tuberculosis virus-infection crohns-disease polymorphism promoter hiv-1 resistance diarrhea
Research affiliation: Kiel University
Refereed: Yes
DOI etc.: 10.1007/s00108-011-2858-8
ISSN: 0020-9554
Date Deposited: 01 Nov 2012 04:59
Last Modified: 23 Jan 2013 10:04
URI: http://oceanrep.geomar.de/id/eprint/18257

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