Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo.

Schrader, C., Schiborr, C., Frank, J. and Rimbach, G. (2011) Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo. British Journal of Nutrition, 105 (2). pp. 167-170. DOI 10.1017/s0007114510004356.

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Abstract

Paraoxonase 1 (PON1) is an enzyme that is mainly synthesised in the liver and protects LDL from oxidation, thereby exhibiting antiatherogenic properties. Using a luciferase reporter gene assay, we tested curcumin for its ability to induce PON1 in Huh7 hepatocytes in culture. Curcumin (>= 10 mu mol/l) dose-dependently induced PON1 transactivation in Huh7 cells. However, dietary supplementation of female B6C3F1 mice with curcumin (500 mg/kg diet) for 2 weeks did not increase the hepatic PON1 mRNA and protein levels. No curcumin was detectable in the plasma of the 12 h fasted mice. In conclusion, curcumin may be a potent PON1 inducer in cultured cells in vitro, but not in the liver of curcumin-fed mice because of its low concentrations in vivo.

Document Type: Article
Keywords: Curcumin Paraoxonase Hepatocytes Mice Atherosclerosis lipoprotein associated paraoxonase low-density-lipoprotein gene-expression serum paraoxonase atherosclerosis receptor mice
Research affiliation: Kiel University
Refereed: Yes
Date Deposited: 01 Nov 2012 04:59
Last Modified: 23 Jan 2013 10:01
URI: https://oceanrep.geomar.de/id/eprint/18599

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