Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.

Steininger, A., Mobs, M., Ullmann, R., Kochert, K., Kreher, S., Lamprecht, B., Anagnostopoulos, I., Hummel, M., Richter, J., Beyer, M., Janz, M., Klemke, C. D., Stein, H., Dorken, B., Sterry, W., Schrock, E., Mathas, S. and Assaf, C. (2011) Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. Journal of Experimental Medicine, 208 (8). pp. 1585-1593. DOI 10.1084/jem.20101785.

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Supplementary data:


The transcription factor E2A is essential for lymphocyte development. In this study, we describe a recurrent E2A gene deletion in at least 70 of patients with Sezary syndrome (SS), a subtype of T cell lymphoma. Loss of E2A results in enhanced proliferation and cell cycle progression via derepression of the protooncogene MYC and the cell cycle regulator CDK6. Furthermore, by examining the gene expression profile of SS cells after restoration of E2A expression, we identify several E2A-regulated genes that interfere with oncogenic signaling pathways, including the Ras pathway. Several of these genes are down-regulated or lost in primary SS tumor cells. These data demonstrate a tumor suppressor function of E2A in human lymphoid cells and could help to develop new treatment strategies for human lymphomas with altered E2A activity.

Document Type: Article
Keywords: transcription factor e2a t-cell development sezary-syndrome chromosomal-aberrations enhancer binding proteins expression immunoglobulin notch myc
Research affiliation: Kiel University
Refereed: Yes
DOI etc.: 10.1084/jem.20101785
ISSN: 0022-1007
Date Deposited: 01 Nov 2012 05:07
Last Modified: 23 Jan 2013 10:00

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