Absence of major histocompatibility complex class II mediated immunity in pipefish, Syngnathus typhle: evidence from deep transcriptome sequencing.

Haase, David, Roth, Olivia, Kalbe, M., Schmiedeskamp, G., Scharsack, J. P., Rosenstiel, P. and Reusch, Thorsten B.H. (2013) Absence of major histocompatibility complex class II mediated immunity in pipefish, Syngnathus typhle: evidence from deep transcriptome sequencing. Biology Letters, 9 (2). p. 20130044. DOI 10.1098/rsbl.2013.0044.

[img] Text
Haase_D_etal_2013_BiolLetts.pdf - Published Version
Restricted to Registered users only

Download (340Kb) | Contact
[img] Text
rsbl20130044supp1.doc - Supplemental Material

Download (518Kb)

Supplementary data:

Abstract

The major histocompatibility complex (MHC)-mediated adaptive immune system is the hallmark of gnathostome immune defence. Recent work suggests that cod-like fishes (Gadidae) lack important components of the MHC class II mediated immunity. Here, we report a putative independent loss of functionality of this pathway in another species, the pipefish Syngnathus typhle, that belongs to a distantly related fish family (Syngnathidae). In a deep transcriptome sequencing approach comprising several independent normalized and non-normalized expressed sequence tag (EST) libraries with approximately 7.5 × 108 reads, sequenced with two next generation platforms (454 and Illumina), we were unable to identify MHC class IIα/β genes as well as genes encoding associated receptors. Along with the recent findings in cod, our results suggest that immune systems of the Euteleosts may be more variable than previously assumed.

Document Type: Article
Additional Information: WOS:000331305400008
Keywords: immunity, major histocompatibility complex, syngathidae, pathogen, gene repertoire
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Marine Evolutionary Ecology
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1098/rsbl.2013.0044
ISSN: 1744-9561
Projects: Future Ocean
Date Deposited: 11 Mar 2013 09:47
Last Modified: 17 Jun 2016 12:41
URI: http://oceanrep.geomar.de/id/eprint/20683

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...