Specific immune priming in the invasive ctenophore Mnemiopsis leidyi.

Bolte, Sören, Roth, Olivia, Philipp, E. E. R., Saphörster, Julia, Rosenstiel, Philip and Reusch, Thorsten B.H. (2013) Specific immune priming in the invasive ctenophore Mnemiopsis leidyi. Biology Letters, 9 (6). 20130864 . DOI 10.1098/rsbl.2013.0864.

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Text ( Ctenophore handling and bacteria culturing; Target genes; Q-RT-PCR assay; Statistical analysis; Gene expression)
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Abstract

Specific immune priming enables an induced immune response upon repeated pathogen encounter. As a functional analogue to vertebrate immune memory, such adaptive plasticity has been described, for instance, in insects and crustaceans. However, towards the base of the metazoan tree our knowledge about the existence of specific immune priming becomes scattered. Here, we exposed the invasive ctenophore Mnemiopsis leidyi repeatedly to two different bacterial epitopes (Gram-positive or -negative) and measured gene expression. Ctenophores experienced either the same bacterial epitope twice (homologous treatments) or different bacterial epitopes (heterologous treatments). Our results demonstrate that immune gene expression depends on earlier bacterial exposure. We detected significantly different expression upon heterologous compared with homologous bacterial treatment at three immune activator and effector genes. This is the first experimental evidence for specific immune priming in Ctenophora and generally in non-bilaterian animals, hereby adding to our growing notion of plasticity in innate immune systems across all animal phyla.

Document Type: Article
Additional Information: WOS:000330290400049
Keywords: immune priming; bacteria; invertebrate; ctenophore; basal metazoan; adaptive plasticity
Research affiliation: Kiel University
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Marine Evolutionary Ecology
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EOE-B Experimental Ecology - Benthic Ecology
UNSPECIFIED
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1098/rsbl.2013.0864
ISSN: 1744-9561
Projects: Future Ocean
Date Deposited: 20 Nov 2013 09:58
Last Modified: 17 Jun 2016 12:22
URI: http://oceanrep.geomar.de/id/eprint/22470

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