Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts.

Orhan, Ilkay Erdogan, Sener, Bilge, Kaiser, Marcel, Brun, Reto and Tasdemir, Deniz (2013) Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts. Türk Biyokimya Dergisi / Turkish Journal of Biochemistry, 38 (4). pp. 403-408. DOI 10.5505/tjb.2013.07379.

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Supplementary data:

Abstract

Objective:
the aim of this study is to investigate the in vitro antioxidant activity, the total phenol and flavonoid content and the possible protective effects of commercial propolis on
gentamicin-induced nephrotoxicity in rabbits.
Methods:
the in vitro antioxidant activity was measured by ferric reducing antioxidant power assay and cupric reducing antioxidant capacity assay, the total phenols content was measured by folin–ciocalteau assay, the flavonoids content by the alcl3 colorimetric method and the renoprotective effects of propolis methanol extract was evaluated in a rabbit model of
gentamicin-induced nephrotoxicity. The protective effects of propolis on gentamicin-induced nephrotoxicity in rabbits were evaluated through biochemical parameter (measuring serum urea and creatinine) and histopathological alterations in kidneys
Results:
methanol extract of propolis showed a strong antioxidant activity, which is attributed to its high phenolic and flavonoid contents. Oral administration of propolis extract to rabbits at a dose of 1 mg/kg body weight significantly protected against histopathological and biochemical alterations induced by gentamicin.
Conclusion:
the present study demonstrated that commercial propolis is strong antioxidant and is effective for the prevention of gentamicin-induced renal damage in rabbits

Document Type: Article
Keywords: Lycopodium, Lycopodiaceae, antiprotozoal activity, cytotoxicity
Refereed: Yes
Open Access Journal?: Yes
Publisher: Turkish Biochemical Society
Date Deposited: 27 Aug 2014 10:25
Last Modified: 30 Apr 2020 12:23
URI: https://oceanrep.geomar.de/id/eprint/23460

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