Bisabolane type sesquiterpenes from a marine Didiscus sponge.

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Tasdemir, Deniz , Bugni, T. S., Mangalindan, G. C., Concepcion, G. P., Harper, M. K. and Ireland, D. M. (2003) Bisabolane type sesquiterpenes from a marine Didiscus sponge. Turkish Journal of Chemistry, 27 (2). pp. 273-279.

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Abstract

Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to b -sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR, [a]D, EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.

Document Type: Article
Keywords: Marine sponge, Didiscus, (+)-curcuphenol, (+)-curcudiol, b -sitosterol, phenethylamine, HCT-116
Refereed: Yes
Open Access Journal?: Yes
Publisher: Tübitak
Date Deposited: 12 Aug 2014 12:57
Last Modified: 30 Apr 2020 12:35
URI: https://oceanrep.geomar.de/id/eprint/23544

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