Understanding complex host-microbe interactions in Hydra.

Bosch, Thomas (2012) Understanding complex host-microbe interactions in Hydra. Gut Microbes, 3 (4). pp. 345-51. DOI 10.4161/gmic.20660.

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Any multicellular organism may be considered a metaorganism or holobiont—comprised of the macroscopic host and synergistic interdependence with bacteria, archaea, fungi, viruses, and numerous other microbial and eukaryotic species including algal symbionts. Defining the individual microbe-host conversations in these consortia is a challenging but necessary step on the path to understanding the function of the associations as a whole. Dissecting the fundamental principles that underlie all host-microbe interactions requires simple animal models with only a few specific bacterial species. Here I present Hydra as such a model with one of the simplest epithelia in the animal kingdom, with the availability of a fully sequenced genome and numerous genomic tools, and with few associated bacterial species.

Document Type: Article
Keywords: cnidaria, innate immunity, commensal microbiota, epithelial cells
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.4161/gmic.20660
ISSN: 1949-0976
Projects: Future Ocean
Date Deposited: 14 May 2014 10:19
Last Modified: 23 Sep 2019 20:56
URI: http://oceanrep.geomar.de/id/eprint/23866

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