A Novel Sarcoidosis Risk Locus for Europeans on Chromosome 11q13.1.

Fischer, Annegret, Schmid, Benjamin, Ellinghaus, David, Nothnagel, Michael, Gaede, Karoline I., Schuermann, Manfred, Lipinski, Simone, Rosenstiel, Philip, Zissel, Gernot, Hoehne, Kerstin, Petrek, Martin, Kolek, Vitezslav, Pabst, Stefan, Grohe, Christian, Grunewald, Johan, Ronninger, Marcus, Eklund, Anders, Padyukov, Leonid, Gieger, Christian, Wichmann, H. Erich, Nebel, Almut, Franke, Andre, Mueller-Quernheim, Joachim, Hofmann, Sylvia and Schreiber, Stefan (2012) A Novel Sarcoidosis Risk Locus for Europeans on Chromosome 11q13.1. American Journal of Respiratory and Critical Care Medicine, 186 (9). pp. 877-885. DOI 10.1164/rccm.201204-0708oc.

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Abstract

Rationale: Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. Objectives: To identify additional risk loci for sarcoidosis and its acute and chronic subforms, we analyzed imputed data from a genomewide association scan for these phenotypes. Methods: After quality control, the genome-wide association scan comprised nearly 1.3 million imputed single-nucleotide polymorphisms based on an Affymetrix 6.0 Gene Chip dataset of 564 German sarcoidosis cases, including 176 acute and 354 chronic cases and 1,575 control subjects. Measurements and Main Results: We identified chromosome 11q13.1 (rs479777) as a novel locus influencing susceptibility to sarcoidosis with genome-wide significance. The marker was significantly associated in three distinct German case-control populations and in an additional German family sample with odds ratios ranging from 0.67 to 0.77. This finding was further replicated in two independent European case-control populations from the Czech Republic (odds ratio, 0.75) and from Sweden (odds ratio, 0.79). In a meta-analysis of the included European case-control samples the marker yielded a P value of 2.68 x 10(-18). The locus was previously reported to be associated with Crohn disease, psoriasis, alopecia areata, and leprosy. For sarcoidosis, fine-mapping and expression analysis suggest KCNK4, PRDX5, PCLB3, and most promising CCDC88B as candidates for the underlying risk gene in the associated region. Conclusions: This study provides striking evidence for association of chromosome 11q13.1 with sarcoidosis in Europeans, and thus identified a further genetic risk locus shared by sarcoidosis, Crohn disease and psoriasis.

Document Type: Article
Keywords: sarcoidosis; genome-wide association study; imputation; Gipie; PRDX5
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1164/rccm.201204-0708oc
ISSN: 1073-449X
Projects: Future Ocean
Date Deposited: 14 May 2014 10:12
Last Modified: 31 Jul 2019 06:45
URI: http://oceanrep.geomar.de/id/eprint/23920

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