MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers.

Franzenburg, Soeren, Fraune, Sebastian, Kuenzel, Sven, Baines, John F., Domazet-Loso, Tomislav and Bosch, Thomas (2012) MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. PNAS Proceedings of the National Academy of Sciences of the United States of America, 109 (47). pp. 19374-19379. DOI 10.1073/pnas.1213110109.

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Supplementary data:

Abstract

Toll-like receptor (TLR) signaling is one of the most important signaling cascades of the innate immune system of vertebrates. Studies in invertebrates have focused on the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, and there is little information regarding the evolutionary origin and ancestral function of TLR signaling. In Drosophila, members of the Toll-like receptor family are involved in both embryonic development and innate immunity. In C. elegans, a clear immune function of the TLR homolog TOL-1 is controversial and central components of vertebrate TLR signaling including the key adapter protein myeloid differentiation primary response gene 88 (MyD88) and the transcription factor NF-κB are not present. In basal metazoans such as the cnidarians Hydra magnipapillata and Nematostella vectensis, all components of the vertebrate TLR signaling cascade are present, but their role in immunity is unknown. Here, we use a MyD88 loss-of-function approach in Hydra to demonstrate that recognition of bacteria is an ancestral function of TLR signaling and that this process contributes to both host-mediated recolonization by commensal bacteria as well as to defense against bacterial pathogens.

Document Type: Article
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1073/pnas.1213110109
ISSN: 0027-8424
Projects: Future Ocean
Date Deposited: 14 May 2014 10:12
Last Modified: 31 Jul 2019 06:40
URI: http://oceanrep.geomar.de/id/eprint/23968

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