Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans.

Fraune, Johanna, Alsheimer, Manfred, Volff, Jean-Nicolas, Busch, Karoline, Fraune, Sebastian, Bosch, Thomas and Benavente, Ricardo (2012) Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans. PNAS Proceedings of the National Academy of Sciences of the United States of America, 109 (41). pp. 16588-16593. DOI 10.1073/pnas.1206875109.

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Abstract

The synaptonemal complex (SC) is a key structure of meiosis, mediating the stable pairing (synapsis) of homologous chromosomes during prophase I. Its remarkable tripartite structure is evolutionarily well conserved and can be found in almost all sexually reproducing organisms. However, comparison of the different SC protein components in the common meiosis model organisms Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealed no sequence homology. This discrepancy challenged the hypothesis that the SC arose only once in evolution. To pursue this matter we focused on the evolution of SYCP1 and SYCP3, the two major structural SC proteins of mammals. Remarkably, our comparative bioinformatic and expression studies revealed that SYCP1 and SYCP3 are also components of the SC in the basal metazoan Hydra. In contrast to previous assumptions, we therefore conclude that SYCP1 and SYCP3 form monophyletic groups of orthologous proteins across metazoans.

Document Type: Article
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1073/pnas.1206875109
ISSN: 0027-8424
Projects: Future Ocean
Date Deposited: 14 May 2014 10:11
Last Modified: 23 Sep 2019 23:39
URI: http://oceanrep.geomar.de/id/eprint/23969

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