Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp Tu 6392.

Schulz, Dirk, Nachtigall, Jonny, Geisen, Ulf, Kalthoff, Holger, Imhoff, Johannes F., Fiedler, Hans-Peter and Suessmuth, Roderich D. (2012) Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp Tu 6392. Journal of Antibiotics, 65 (7). pp. 369-372. DOI 10.1038/ja.2012.33.

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Abstract

Streptomycetes were isolated out of a soil sample taken from the rhizosphere of a spruce stand and screened by HPLC-diode array analysis for the production of secondary metabolites. This led to the detection of silvalactam, a novel 24-membered macrolactam antibiotic in extracts of Streptomyces strain Tu 6392. The structure was determined by MS and NMR spectroscopy experiments. Silvalactam shows a potent antiproliferative activity against various cancerous and non-cancerous cell lines. The Journal of Antibiotics (2012) 65, 369-372; doi: 10.1038/ja.2012.33; published online 9 May 2012

Document Type: Article
Additional Information: WOS:000306921500006
Keywords: antitumor agent; 24-membered macrolactam antibiotic; Streptomyces
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1038/ja.2012.33
ISSN: 0021-8820
Projects: Future Ocean
Date Deposited: 12 May 2014 10:00
Last Modified: 21 Nov 2016 15:10
URI: http://oceanrep.geomar.de/id/eprint/24251

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