Chrysosporide, a Cyclic Pentapeptide from a New Zealand Sample of the Fungus Sepedonium chrysospermum.

Mitova, Maya I., Stuart, B.G., Cao, G.H., Blunt, J.W., Cole, A.L.J. and Munro, M.H.G. (2006) Chrysosporide, a Cyclic Pentapeptide from a New Zealand Sample of the Fungus Sepedonium chrysospermum. Journal of Natural Products, 69 . pp. 1481-1484. DOI 10.1021/np060137o.

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Abstract

A new cyclic pentapeptide, chrysosporide (1), was isolated from a New Zealand sample of the mycoparasitic fungus Sepedonium chrysospermum by bioactivity-guided fractionation. The planar structure was deduced by detailed spectroscopic analysis, and the absolute configurations of the amino acid residues were defined by Marfey's method. As both enantiomers of Leu occurred in chrysosporide, molecular mechanics calculations were applied to the analysis to distinguish between the possible structural isomers. Only the lowest energy conformers of the cyclo-(l-Val-d-Ala-l-Leu-l-Leu-d-Leu) isomer were in agreement with the observed NOEs, suggesting that this was the most probable amino acid sequence for chrysosporide (1).

Document Type: Article
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/np060137o
ISSN: 0163-3864
Date Deposited: 03 Dec 2008 16:51
Last Modified: 30 Apr 2018 12:20
URI: http://oceanrep.geomar.de/id/eprint/2427

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