Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106.

Wu, Bin, Oesker, Vanessa, Wiese, Jutta , Schmaljohann, Rolf and Imhoff, Johannes F. (2014) Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106. Open Access Marine Drugs, 12 (3). pp. 1208-1219. DOI 10.3390/md12031208.

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Abstract

Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively.

Document Type: Article
Additional Information: WOS:000335752800003
Keywords: pyridones; antibiotic; Trichoderma; marine fungus
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.3390/md12031208
ISSN: 1660-3397
Projects: KIWIZ, Future Ocean
Date Deposited: 24 Apr 2014 08:33
Last Modified: 02 Mar 2018 12:50
URI: http://oceanrep.geomar.de/id/eprint/24371

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