Nature’s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain.

Kunz, Anna Lena, Labes, Antje, Wiese, Jutta , Bruhn, Torsten, Bringmann, Gerhard and Imhoff, Johannes F. (2014) Nature’s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain. Open Access Marine Drugs, 12 (4). pp. 1699-1714. DOI 10.3390/md12041699.

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Abstract

Eight streptophenazines (A–H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I–K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I–K) also showed moderate activities against PDE 4B.

Document Type: Article
Additional Information: WOS:000335759500001
Keywords: marine natural product; phenazine; Baltic Sea; Streptomyces; Halichondria panicea; HPLC-DAD/MS; fermentation; PDE 4; antibiotic
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.3390/md12041699
ISSN: 1660-3397
Projects: KIWIZ, Future Ocean
Date Deposited: 24 Apr 2014 08:37
Last Modified: 02 Mar 2018 12:48
URI: http://oceanrep.geomar.de/id/eprint/24372

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