Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8.

Bayram, B., Nikolai, S., Huebbe, P., Ozcelik, B., Grimm, S., Grune, T., Frank, J. and Rimbach, Gerald (2013) Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8. AGE, 35 (4). pp. 1205-1217. DOI 10.1007/s11357-012-9448-0.

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Supplementary data:

Abstract

In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n = 10 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit β-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and α-tocopherol in the liver. An age-dependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice.

Document Type: Article
Additional Information: Times Cited: 1 Bayram, Banu Nikolai, Sibylle Huebbe, Patricia Ozcelik, Beraat Grimm, Stefanie Grune, Tilman Frank, Jan Rimbach, Gerald
Keywords: SAMP8 Accelerated ageing Stress response Proteasomal activity Ascorbic acid Tocopherol
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
Publisher: American Medical Association
Projects: Future Ocean
Date Deposited: 08 Jul 2014 08:51
Last Modified: 23 Sep 2019 20:51
URI: https://oceanrep.geomar.de/id/eprint/24824

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