Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans.

Egert, S., Tereszczuk, J., Wein, S., Muller, M. J., Frank, J., Rimbach, Gerald and Wolffram, S. (2013) Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. European Journal of Nutrition, 52 (1). pp. 281-288. DOI 10.1007/s00394-012-0330-8.

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Supplementary data:

Abstract

Purpose
To investigate the influence of dietary proteins (casein, soy protein) and skimmed milk on the plasma kinetics of green tea (GT) catechins.
Methods
In a randomized cross-over design with one-week intervals, 24 healthy normal-weight women consumed a test drink containing 1.75 g GT extract with or without the addition of different proteins. Treatments were GT (control), GT with skimmed milk (GT + M), GT with caseinate (GT + CS), or GT with soy protein (GT + S). Venous blood samples were taken before and several times during a period of 4.5 h after consumption of the test drink. Plasma concentrations of catechins were analyzed by HPLC with electrochemical detection.
Results
Compared to control, consumption of GT with milk, caseinate, or soy protein significantly reduced the bioavailability (mean area under the plasma concentration–time curve) of total catechins (means ± SEM; GT + M, 87 ± 5%; GT + CS, 79 ± 5%; GT + S, 88 ± 4%), epigallocatechin gallate (GT + M, 68 ± 4%; GT + CS, 63 ± 5%; GT + S, 76 ± 5%), and epicatechin gallate (GT + M, 68 ± 5%; GT + CS, 66 ± 6%; GT + S, 77 ± 6%), while the bioavailability of non-galloylated catechins such as epigallocatechin (GT + M, 134 ± 9%; GT + CS, 118 ± 9 %; GT + S, 123 ± 8%) and epicatechin (GT + M, 125 ± 10%; GT + CS, 114 ± 11%; GT + S, 110 ± 8%) significantly increased. No significant differences in bioavailability of GT catechins were observed between the treatments GT + M, GT + CS, or GT + S.
Conclusion
Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from GT in humans.

Document Type: Article
Additional Information: Times Cited: 1 Egert, Sarah Tereszczuk, Jane Wein, Silvia Mueller, Manfred James Frank, Jan Rimbach, Gerald Wolffram, Siegfried
Keywords: Catechins Flavan-3-ols Bioavailability Dietary protein Human study
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1007/s00394-012-0330-8
ISSN: 1436-6207
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:09
Last Modified: 16 Jul 2019 10:18
URI: http://oceanrep.geomar.de/id/eprint/24897

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