Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies.

Ellinghaus, D., Zhang, H., Zeissig, S., Lipinski, S., Till, A., Jiang, T., Stade, B., Bromberg, Y., Ellinghaus, E., Keller, A., Rivas, M. A., Skieceviciene, J., Doncheva, N. T., Liu, X., Liu, Q., Jiang, F. M., Forster, M., Mayr, G., Albrecht, M., Hasler, R., Boehm, B. O., Goodall, J., Berzuini, C. R., Lee, J., Andersen, V., Vogel, U., Kupcinskas, L., Kayser, M., Krawczak, M., Nikolaus, S., Weersma, R. K., Ponsioen, C. Y., Sans, M., Wijmenga, C., Strachan, D. P., McAardle, W. L., Vermeire, S., Rutgeerts, P., Sanderson, J. D., Mathew, C. G., Vatn, M. H., Wang, J., Nothen, M. M., Duerr, R. H., Buning, C., Brand, S., Glas, J., Winkelmann, J., Illig, T., Latiano, A., Annese, V., Halfvarson, J., D'Amato, M., Daly, M. J., Nothnagel, M., Karlsen, T. H., Subramani, S., Rosenstiel, Philip, Schreiber, Stefan, Parkes, M. and Franke, A. (2013) Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies. Gastroenterology, 145 (2). pp. 339-347. DOI 10.1053/j.gastro.2013.04.040.

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Supplementary data:

Abstract

Genome-wide association studies (GWAS) have identified 140 Crohn’s disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies.

Document Type: Article
Additional Information: Times Cited: 4 Ellinghaus, David Zhang, Hu Zeissig, Sebastian Lipinski, Simone Till, Andreas Jiang, Tao Stade, Bjoern Bromberg, Yana Ellinghaus, Eva Keller, Andreas Rivas, Manuel A. Skieceviciene, Jurgita Doncheva, Nadezhda T. Liu, Xiao Liu, Qing Jiang, Fuman Forster, Michael Mayr, Gabriele Albrecht, Mario Haesler, Robert Boehm, Bernhard O. Goodall, Jane Berzuini, Carlo R. Lee, James Andersen, Vibeke Vogel, Ulla Kupcinskas, Limas Kayser, Manfred Krawczak, Michael Nikolaus, Susanna Weersma, Rinse K. Ponsioen, Cyriel Y. Sans, Miquel Wijmenga, Cisca Strachan, David P. McAardle, Wendy L. Vermeire, Severine Rutgeerts, Paul Sanderson, Jeremy D. Mathew, Christopher G. Vatn, Morten H. Wang, Jun Noethen, Markus M. Duerr, Richard H. Buening, Carsten Brand, Stephan Glas, Juergen Winkelmann, Juliane Illig, Thomas Latiano, Anna Annese, Vito Halfvarson, Jonas D'Amato, Mauro Daly, Mark J. Nothnagel, Michael Karlsen, Tom H. Subramani, Suresh Rosenstiel, Philip Schreiber, Stefan Parkes, Miles Franke, Andre
Keywords: Inflammatory Bowel Disease, Whole-Exome Sequencing, Complex Disease
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1053/j.gastro.2013.04.040
ISSN: 0016-5085
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:10
Last Modified: 23 Aug 2019 09:33
URI: http://oceanrep.geomar.de/id/eprint/24902

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