Vitamin E supplementation and lifespan in model organisms.

Ernst, I. M. A., Pallauf, K., Bendall, J. K., Paulsen, L., Nikolai, S., Huebbe, P., Roeder, T. and Rimbach, Gerald (2013) Vitamin E supplementation and lifespan in model organisms. Ageing Research Reviews, 12 (1). pp. 365-375. DOI 10.1016/j.arr.2012.10.002.

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Supplementary data:


We have conducted a comprehensive literature review regarding the effect of vitamin E on lifespan in model organisms including single-cell organisms, rotifers, Caenorhabditis elegans, Drosophila melanogaster and laboratory rodents. We searched Pubmed and ISI Web of knowledge for studies up to 2011 using the terms “tocopherols”, “tocotrienols”, “lifespan” and “longevity” in the above mentioned model organisms. Twenty-four studies were included in the final analysis. While some studies suggest an increase in lifespan due to vitamin E, other studies did not observe any vitamin E-mediated changes in lifespan in model organisms. Furthermore there are several studies reporting a decrease in lifespan in response to vitamin E supplementation. Different outcomes between studies may be partly related to species-specific differences, differences in vitamin E concentrations and the vitamin E congeners administered. The findings of our literature review suggest that there is no consistent beneficial effect of vitamin E on lifespan in model organisms which is consistent with reports in human intervention studies.

Document Type: Article
Additional Information: Times Cited: 5 Ernst, I. M. A. Pallauf, K. Bendall, J. K. Paulsen, L. Nikolai, S. Huebbe, P. Roeder, T. Rimbach, G. 2013
Keywords: Vitamin E, Tocopherol, Tocotrienol, Lifespan, Longevity, Model organisms
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1016/j.arr.2012.10.002
ISSN: 1568-1637
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:11
Last Modified: 24 Sep 2019 00:04

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