Distinct antimicrobial peptide expression determines host species-specific bacterial associations.

Franzenburg, S., Walter, J., Kunzel, S., Wang, J., Baines, J. F., Bosch, T. C. G. and Fraune, Sebastian (2013) Distinct antimicrobial peptide expression determines host species-specific bacterial associations. PNAS Proceedings of the National Academy of Sciences of the United States of America, 110 (39). E3730-E3738. DOI 10.1073/pnas.1304960110.

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Supplementary data:

Abstract

Animals are colonized by coevolved bacterial communities, which contribute to the host’s health. This commensal microbiota is often highly specific to its host-species, inferring strong selective pressures on the associated microbes. Several factors, including diet, mucus composition, and the immune system have been proposed as putative determinants of host-associated bacterial communities. Here we report that species-specific antimicrobial peptides account for different bacterial communities associated with closely related species of the cnidarian Hydra. Gene family extensions for potent antimicrobial peptides, the arminins, were detected in four Hydra species, with each species possessing a unique composition and expression profile of arminins. For functional analysis, we inoculated arminin-deficient and control polyps with bacterial consortia characteristic for different Hydra species and compared their selective preferences by 454 pyrosequencing of the bacterial microbiota. In contrast to control polyps, arminin-deficient polyps displayed decreased potential to select for bacterial communities resembling their native microbiota. This finding indicates that species-specific antimicrobial peptides shape species-specific bacterial associations.

Document Type: Article
Additional Information: Times Cited: 1 Franzenburg, Soeren Walter, Jonas Kuenzel, Sven Wang, Jun Baines, John F. Bosch, Thomas C. G. Fraune, Sebastian
Keywords: host-microbe, Cnidaria, phylosymbiotic, core microbiota, holobiont
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1073/pnas.1304960110
ISSN: 0027-8424
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:19
Last Modified: 22 Jul 2019 10:43
URI: http://oceanrep.geomar.de/id/eprint/24924

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