Huge increase of therapeutic window at a bioactive silver/titania nanocomposite coating surface compared to solution.

Hrkac, T., Rohl, C., Podschun, R., Zaporojtchenko, V., Strunskus, T., Papavlassopoulos, H., Garbe-Schönberg, Dieter and Faupel, F. (2013) Huge increase of therapeutic window at a bioactive silver/titania nanocomposite coating surface compared to solution. Materials Science & Engineering C, 33 (4). pp. 2367-2375. DOI 10.1016/j.msec.2013.01.069.

Full text not available from this repository.

Supplementary data:

Abstract

A silver containing coating used in the human body, e.g., on an implant should be both effectively antimicrobial and non-cytotoxic to human cells. It is generally believed that the biologic effect originates from silver ions released from the coating. Nanocomposites with well controlled Ag filling factor were prepared by co-sputtering, and the silver surface concentration and the silver release were determined by XPS and ICP-MS, respectively. Here we show that only a small therapeutic window exists for dissolved silver but the therapeutic window is largely increased at the surface. While the toxicity observed for mammalian cells in contact with the bioactive Ag/TiO2 nanocomposite surface and for silver ions in solution is rather similar the antimicrobial activity is drastically enhanced at the surface. A model is proposed to explain the strong increase of the antimicrobial activity at the surface. The present results not only question well-established tests for antimicrobial activity but they are also important for the design of antimicrobial coatings, e.g., for biomedical devices.

Document Type: Article
Keywords: Silver, Titanium oxide, Nanocomposite, Antimicrobial, Cytotoxicity, Therapeutic window
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
Publisher: Elsevier
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:24
Last Modified: 23 Sep 2019 22:18
URI: https://oceanrep.geomar.de/id/eprint/25010

Actions (login required)

View Item View Item