Higher Fetuin-A Level Is Associated with Coexistence of Elevated Alanine Aminotransferase and the Metabolic Syndrome in the General Population.

Koch, M., Jacobs, G., Hampe, J., Rosenstiel, Philip, Krawczak, Michael and Nothlings, U. (2013) Higher Fetuin-A Level Is Associated with Coexistence of Elevated Alanine Aminotransferase and the Metabolic Syndrome in the General Population. Metabolic Syndrome and Related Disorders, 11 (6). pp. 377-384. DOI 10.1089/met.2013.0078.

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Supplementary data:

Abstract

Background: Higher fetuin-A levels have been linked to fatty liver disease (FLD), the most common cause of elevated alanine aminotransferase (ALT) levels, but associations between ALT and fetuin-A level have been inconsistent. The presence of the metabolic syndrome in individuals with elevated ALT levels has been shown to characterize more severe FLD. Thus, aim of the study was to investigate the association between fetuin-A level and the coexistence of elevated ALT levels and metabolic syndrome (ALT-MetS).
Methods: A population-based cross-sectional study including 728 individuals (age 50–77 years) was conducted. We used multivariable logistic regression analysis to assess the association between serum fetuin-A level and the dichotomous outcome ALT-MetS, defined as coexistence of elevated ALT level (>75th percentile) and metabolic syndrome (any three of the components: abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, abnormal glucose metabolism).
Results: Individuals with a high fetuin-A level had an odds ratio (OR) for ALT-MetS of 2.22 [95% confidence interval (CI) 1.36–3.63; Ptrend=<0.001] comparing extreme tertiles. After excluding individuals with cancer, stroke, or myocardial infarction, individuals with high fetuin-A levels had an OR for ALT-MetS of 2.48 (95% CI 1.38–4.47) comparing extreme tertiles, and we observed statistical interaction between fetuin-A level and age (P=0.048). Fetuin-A level was associated with ALT-MetS in young individuals, defined as <64 years of age (OR 3.30, 95% CI 1.45–7.55; Ptrend=0.004), and not statistically significant in older individuals (OR 1.79, 95% CI 0.74–4.31; Ptrend=0.197).
Conclusions: Fetuin-A level was positively associated with ALT-MetS, particularly in younger individuals. Prospective studies in larger populations are warranted.

Document Type: Article
Additional Information: Times Cited: 0 Koch, Manja Jacobs, Gunnar Hampe, Jochen Rosenstiel, Philip Krawczak, Michael Noethlings, Ute
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1089/met.2013.0078
ISSN: 1540-4196
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:27
Last Modified: 24 Sep 2019 00:06
URI: http://oceanrep.geomar.de/id/eprint/25031

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