Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut Microbiota.

Perez-Cobas, A. E., Artacho, A., Knecht, H., Ferrus, M. L., Friedrichs, A., Ott, Stephan, Moya, A., Latorre, A. and Gosalbes, M. J. (2013) Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut Microbiota. Open Access PLoS ONE, 8 (11). DOI 10.1371/journal.pone.0080201.

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Abstract

The human intestinal microbiota performs many essential functions for the host. Antimicrobial agents, such as antibiotics (AB), are also known to disturb microbial community equilibrium, thereby having an impact on human physiology. While an increasing number of studies investigate the effects of AB usage on changes in human gut microbiota biodiversity, its functional effects are still poorly understood. We performed a follow-up study to explore the effect of ABs with different modes of action on human gut microbiota composition and function. Four individuals were treated with different antibiotics and samples were taken before, during and after the AB course for all of them. Changes in the total and in the active (growing) microbiota as well as the functional changes were addressed by 16S rRNA gene and metagenomic 454-based pyrosequencing approaches. We have found that the class of antibiotic, particularly its antimicrobial effect and mode of action, played an important role in modulating the gut microbiota composition and function. Furthermore, analysis of the resistome suggested that oscillatory dynamics are not only due to antibiotic-target resistance, but also to fluctuations in the surviving bacterial community. Our results indicated that the effect of AB on the human gut microbiota relates to the interaction of several factors, principally the properties of the antimicrobial agent, and the structure, functions and resistance genes of the microbial community.

Document Type: Article
Additional Information: Times Cited: 0 Elena Perez-Cobas, Ana Artacho, Alejandro Knecht, Henrik Ferrus, Maria Loreto Friedrichs, Anette Ott, Stephan J. Moya, Andres Latorre, Amparo Jose Gosalbes, Maria
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1371/journal.pone.0080201
ISSN: 1932-6203
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:36
Last Modified: 23 Sep 2019 20:13
URI: http://oceanrep.geomar.de/id/eprint/25129

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