Gut microbiota disturbance during antibiotic therapy: a multi-omic approach.

Perez-Cobas, A. E., Gosalbes, M. J., Friedrichs, A, Knecht, H, Artacho, A, Eismann, K, Otto, W, Rojo, D, Bargiela, R, von Bergen, M, Neulinger, S. C., Daumer, C, Heinsen, F. A., Latorre, A, Barbas, C, Seifert, J, dos Santos, V. M., Ott, Stephan, Ferrer, M and Moya, A (2013) Gut microbiota disturbance during antibiotic therapy: a multi-omic approach. Gut Microbes, 62 (11). pp. 1591-1601. DOI 10.4161/gmic.27128.

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Abstract

It is known that the gastrointestinal tract (GIT) microbiota responds to different antibiotics in different ways and that while some antibiotics do not induce disturbances of the community, others drastically influence the richness, diversity, and prevalence of bacterial taxa. However, the metabolic consequences thereof, independent of the degree of the community shifts, are not clearly understood. In a recent article, we used an integrative OMICS approach to provide new insights into the metabolic shifts caused by antibiotic disturbance. The study presented here further suggests that specific bacterial lineage blooms occurring at defined stages of antibiotic intervention are mostly associated with organisms that possess improved survival and colonization mechanisms, such as those of the Enterococcus, Blautia, Faecalibacterium, and Akkermansia genera. The study also provides an overview of the most variable metabolic functions affected as a consequence of a β-lactam antibiotic intervention. Thus, we observed that anabolic sugar metabolism, the production of acetyl donors and the synthesis and degradation of intestinal/colonic epithelium components were among the most variable functions during the intervention. We are aware that these results have been established with a single patient and will require further confirmation with a larger group of individuals and with other antibiotics. Future directions for exploration of the effects of antibiotic interventions are discussed.

Document Type: Article
Additional Information: Times Cited: 8 Elena Perez-Cobas, Ana Jose Gosalbes, Maria Friedrichs, Anette Knecht, Henrik Artacho, Alejandro Eismann, Kathleen Otto, Wolfgang Rojo, David Bargiela, Rafael von Bergen, Martin Neulinger, Sven C. Daeumer, Carolin Heinsen, Femke-Anouska Latorre, Amparo Barbas, Coral Seifert, Jana dos Santos, Vitor Martins Ott, Stephan J. Ferrer, Manuel Moya, Andres
Keywords: antibiotic therapy, human gut microbiota, metagenomic, metaproteomic, metabolomic, metatranscriptomic
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.4161/gmic.27128
ISSN: 1949-0976
Projects: Future Ocean
Date Deposited: 08 Jul 2014 09:36
Last Modified: 29 Jul 2019 10:06
URI: http://oceanrep.geomar.de/id/eprint/25130

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