R-alpha lipoic acid gamma-cyclodextrin complex increases energy expenditure: A 4-month feeding study in mice.

Nikolai, Sibylle, Huebbe, Patricia, Metges, Cornelia C., Schloesser, Anke, Dose, Janina, Ikuta, Naoko, Terao, Keiji, Matsugo, Seiichi and Rimbach, Gerald (2014) R-alpha lipoic acid gamma-cyclodextrin complex increases energy expenditure: A 4-month feeding study in mice. Nutrition, 30 (2). pp. 228-233.

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Abstract

Objective: A high-fat diet (HFD) affects energy expenditure in laboratory rodents. R-alpha lipoic acid cyclodextrin (RALA-CD) complex is a stable form of lipoic acid (LA) and may improve energy expenditure. The aim of this study was to determine the effect of RALA-CD on energy expenditure and underlying molecular targets in female laboratory mice. Methods: Female C57BL/6J mice were fed a HFD containing 0.1% LA for about 16 wk. The effects on energy expenditure, gene and protein expression were assessed using indirect calorimetry, real-time reverse transcriptase polymerase chain reaction, and Western blot, respectively. Results: Supplementing mice with RALA-CD resulted in a significant increase in energy expenditure. However, both RALA per se (without gamma-cyclodextrin) and S-cc lipoic acid cyclodextrin did not significantly alter energy expenditure. Furthermore RALA-CD changed expression of genes encoding proteins centrally involved in energy metabolism. Transcriptional key regulators sirtuin 3 and peroxisome proliferator-activated receptor-gamma, coactivator 1 alpha, as well as thyroid related enzyme type 2 iodothyronine deiodinase were up-regulated in brown adipose tissue (BAT) of RALA-CD-fed mice. Importantly, mRNA and/or protein expression of downstream effectors uncoupling protein (Ucp) 1 and 3 also were elevated in BAT from RALA-CD-supplemented mice. Conclusion: Overall, present data suggest that RALA-CD is a regulator of energy expenditure in laboratory mice. (C) 2014 Elsevier Inc. All rights reserved.

Document Type: Article
Additional Information: Times Cited: 1 0 1
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:35
Last Modified: 23 Sep 2019 18:32
URI: https://oceanrep.geomar.de/id/eprint/28085

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