Onur, Simone, Niklowitz, Petra, Fischer, Alexandra, Metges, Cornelia C., Grune, Tilman, Menke, Thomas, Rimbach, Gerald and Doering, Frank (2014) A comparative study into alterations of coenzyme Q redox status in ageing pigs, mice, and worms. BioFactors, 40 (3). pp. 346-354. DOI 10.1002/biof.1160.

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Abstract

Coenzyme Q derivatives (CoQ) are lipid soluble antioxidants that are synthesized endogenously in almost all species and function as an obligatory cofactor of the respiratory chain. There is evidence that CoQ status is altered by age in several species. Here we determined level and redox-state of CoQ in different age groups of pigs, mice and Caenorhabditis elegans. Since these species are very different with respect to lifespan, reproduction and physiology, our approach could provide some general tendencies of CoQ status in ageing organisms. We found that CoQ level decreases with age in pigs and mice, whereas CoQ content increases in older worms. As observed in all three species, ubiquinone, the oxidized form of CoQ, increases with age. Additionally, we were able to show that supplementation of ubiquinol-10, the reduced form of human CoQ(10), slightly increases lifespan of post-reproductive worms. In conclusion, the percentage of the oxidized form of CoQ increases with age indicating higher oxidative stress or rather a decreased anti-oxidative capacity of aged animals. (C) 2014 BioFactors

Document Type:	Article
Additional Information:	Times Cited: 1 0 1
Keywords:	ubiquinol ubiquinone anti‐oxidative capacity oxidative stress antioxidants
Research affiliation:	Kiel University Kiel University > Kiel Marine Science OceanRep > The Future Ocean - Cluster of Excellence
Refereed:	Yes
Open Access Journal?:	No
Publisher:	American Medical Association
Projects:	Future Ocean
Date Deposited:	30 Mar 2015 12:36
Last Modified:	24 Sep 2019 00:00
URI:	https://oceanrep.geomar.de/id/eprint/28090

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