Sulfated Steroid–Amino Acid Conjugates from the Irish Marine Sponge Polymastia boletiformis.

Smyrniotopoulos, Vangelis, Rae, Margaret, Soldatou, Sylvia, Ding, Yuanqing, Wolff, Carsten, McCormack, Grace, Coleman, Christina, Ferreira, Daneel and Tasdemir, Deniz (2015) Sulfated Steroid–Amino Acid Conjugates from the Irish Marine Sponge Polymastia boletiformis. Open Access Marine Drugs, 13 (4). pp. 1632-1646. DOI 10.3390/md13041632.

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Supplementary data:

Abstract

Antifungal bioactivity-guided fractionation of the organic extract of the sponge Polymastia boletiformis, collected from the west coast of Ireland, led to the isolation of two new sulfated steroid-amino acid conjugates (1 and 2). Extensive 1D and 2D NMR analyses in combination with quantum mechanical calculations of the electronic circular dichroism (ECD) spectra, optical rotation, and 13C chemical shifts were used to establish the chemical structures of 1 and 2. Both compounds exhibited moderate antifungal activity against Cladosporium cucumerinum, while compound 2 was also active against Candida albicans. Marine natural products containing steroidal and amino acid constituents are extremely rare in nature.

Document Type: Article
Additional Information: WOS:000353715900002 (This article belongs to the Special Issue Marine Anti-infective Agents)
Keywords: marine; sponge; Polymastia boletiformis; sulfated steroid; antifungal activity
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MN Marine natural products chemistry
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.3390/md13041632
ISSN: 1660-3397
Date Deposited: 18 May 2015 13:44
Last Modified: 13 Apr 2017 07:45
URI: http://oceanrep.geomar.de/id/eprint/28784

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