Antichlamydial sterol from the Red Sea sponge Callyspongia aff. implexa.

Abdelmohsen, U.R., Cheng, C., Reimer, A., Kozjak-Pavlovic, V., Ibrahim, A.K., Rudel, T., Hentschel, Ute , Edrada-Ebel, R. and Ahmed, S.A. (2015) Antichlamydial sterol from the Red Sea sponge Callyspongia aff. implexa. Planta Medica, 81 (5). pp. 382-387. DOI 10.1055/s-0035-1545721.

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Abstract

Marine sponges are rich sources of natural products exhibiting diverse biological activities. Bioactivity-guided fractionation of the Red Sea sponge Callyspongia aff. implexa led to the isolation of two new compounds, 26,27-bisnorcholest-5,16-dien-23-yn-3β,7α-diol, gelliusterol E (1) and C27-polyacetylene, callimplexen A (2), in addition to the known compound β-sitosterol (3). The structures of the isolated compounds were determined by 1D- and 2D-NMR techniques as well as high-resolution tandem mass spectrometry and by comparison to the literature. The three compounds (1–3) were tested against Chlamydia trachomatis, an obligate intracellular gram-negative bacterium, which is the leading cause of ocular and genital infections worldwide. Only gelliusterol E (1) inhibited the formation and growth of chlamydial inclusions in a dose-dependent manner with an IC50 value of 2.3 µM.

Document Type: Article
Keywords: Callyspongia aff. implexa; Callyspongiidae; sponges; Red Sea; sterol; polyacetylene; Chlamydia trachomatis
Refereed: Yes
Open Access Journal?: No
Publisher: Thieme Verlag
Date Deposited: 03 Jun 2015 10:05
Last Modified: 11 Jun 2020 11:14
URI: https://oceanrep.geomar.de/id/eprint/28921

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