Elicitation of secondary metabolism in actinomycetes.

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Abdelmohsen, Usama Ramadan, Grkovic, Tanja, Balasubramanian, Srikkanth, Kamel, Mohamed Salah, Quinn, Ronald J. and Hentschel, Ute (2015) Elicitation of secondary metabolism in actinomycetes. Biotechnology Advances, 33 (6). pp. 798-811. DOI 10.1016/j.biotechadv.2015.06.003.

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Abstract

Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions. This review focuses on the effects of biological (co-cultivation), chemical, as well as molecular elicitation on secondary metabolism in actinomycetes. Our review covers the literature until June 2014 and exemplifies the diversity of natural products that have been recovered by such approaches from the phylum Actinobacteria.

Document Type: Article
Keywords: Actinomycetes; Elicitation; Co-cultivation; Natural products; Silent gene clusters; Biological activities
Refereed: Yes
Open Access Journal?: Yes
Publisher: Elsevier
Date Deposited: 18 Nov 2015 15:03
Last Modified: 18 Nov 2015 15:03
URI: https://oceanrep.geomar.de/id/eprint/30280

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