Characterization of MHC class II genes in the critically endangered European eel (Anguilla anguilla).

Bracamonte, Seraina E., Baltazar-Soares, Miguel and Eizaguirre, Christophe (2015) Characterization of MHC class II genes in the critically endangered European eel (Anguilla anguilla). Conservation Genetics Resources, 7 (4). pp. 859-870. DOI 10.1007/s12686-015-0501-z.

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Abstract

Many exploited fish species are threatened with collapse and the European eel is no exception. Its abundance has declined dramatically and various reasons account for this, among them the introduction of the invasive swim bladder nematode Anguillicola crassus. For developing an adequate immune response against this parasite, variation at the genes of the major histocompatibility complex (MHC), a key component of the adaptive immune system, might be essential and assessing their diversity might provide critical information for improving conservation strategies. Here, we characterized the MHC class II of the European eel. We provide evidence for relatively high diversity at both MHC IIA and MHC IIB, which contrasts with findings for other endangered species. Furthermore, both genes show signs of site-specific positive selection. The absence of overall positive selection at MHC IIB might, however, suggests that demographic shifts have negatively impacted that gene, thereby possibly reducing the adaptive potential of the European eel.

Document Type: Article
Keywords: Major histocompatibility complex; European eel; Positive selection; Demography
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Marine Evolutionary Ecology
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1007/s12686-015-0501-z
ISSN: 1877-7252
Projects: Future Ocean
Date Deposited: 10 Dec 2015 10:12
Last Modified: 21 Jan 2019 15:53
URI: http://oceanrep.geomar.de/id/eprint/30475

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