Albidopyrone, a new α-pyrone-containing metabolite from marine-derived Streptomyces sp. NTK 227.

Hohmann, Claudia, Schneider, Kathrin, Bruntner, Christina, Brown, Roselyn, Jones, Amanda L, Goodfellow, Michael, Krämer, Marco, Imhoff, Johannes F. , Nicholson, Graeme, Fiedler, Hans-Peter and Süssmuth, Roderich D (2009) Albidopyrone, a new α-pyrone-containing metabolite from marine-derived Streptomyces sp. NTK 227. The Journal of Antibiotics, 62 (2). pp. 75-79. DOI 10.1038/ja.2008.15.

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Abstract

Albidopyrone, a new α-pyrone-containing secondary metabolite, was produced by Streptomyces sp. NTK 227, a strain isolated from Atlantic Ocean sediment and found to be a member of the Streptomyces albidoflavus 16S rRNA gene clade. The structure of the compound was determined by MS and NMR spectroscopy, and found to have a moderate inhibitory activity against protein-tyrosin phosphatase B.

Document Type: Article
Keywords: fermentation; isolation; marine Streptomyces; a-pyrone; protein-phosphatase inhibitor; structure elucidation
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1038/ja.2008.15
ISSN: 0021-8820
Projects: Future Ocean
Date Deposited: 11 Jan 2016 14:25
Last Modified: 27 May 2016 07:38
URI: http://oceanrep.geomar.de/id/eprint/30555

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