Gombapyrones, new α-pyrone metabolites produced by Streptomyces griseoruber Acta 3662.

Helaly, Soleiman, Schneider, Kathrin, Nachtigall, Jonny, Vikineswary, Sabaratnam, Tan, Geok Yuan Annie, Zinecker, Heidi, Imhoff, Johannes F. , Süssmuth, Roderich D. and Fiedler, Hans-Peter (2009) Gombapyrones, new α-pyrone metabolites produced by Streptomyces griseoruber Acta 3662. Journal of Antibiotics, 62 . pp. 445-452. DOI 10.1038/ja.2009.70.

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Abstract

Gombapyrones A–D, new members of the α-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3β.

Document Type: Article
Keywords: fermentation, Isolation, alpha-pyrone, protein-tyrosine phosphatase inhibitor, Streptomyces, structure elucidation
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1038/ja.2009.70
ISSN: 0021-8820
Projects: Future Ocean, ACTAPHARM, ACTINOGEN
Date Deposited: 07 Oct 2009 09:59
Last Modified: 23 Sep 2019 21:25
URI: http://oceanrep.geomar.de/id/eprint/3081

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