Scopularides A and B, cyclodepsipeptides from a marine sponge-derived fungus Scopulariopsis brevicaulis.

Zhiguo, Yu, Lang, Gerhard, Kajahn, Inga, Schmaljohann, Rolf and Imhoff, Johannes F. (2008) Scopularides A and B, cyclodepsipeptides from a marine sponge-derived fungus Scopulariopsis brevicaulis. Journal of Natural Products, 71 . pp. 1052-1054. DOI 10.1021/np070580e.

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Abstract

Two novel cyclodepsipeptides, scopularides A and B, were found in the fungus Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium. In addition, the known fungal metabolite paxilline was identified. The structures of the scopularides were elucidated by NMR, MS, and chemical derivatization methods as cyclo-(3-hydroxy-4-methyldecanoyl−Gly−l-Val−d-Leu−l-Ala−l-Phe) and cyclo-(3-hydroxy-4-methyloctanoyl−Gly−l-Val−d-Leu−l-Ala−l-Phe) for scopularide A and B, respectively. Antibiotic activity against Gram-negative bacteria was absent and against Gram-positive bacteria was weak, but activity against several tumor cell lines was significant at 10 µg/mL.

Document Type: Article
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/np070580e
ISSN: 0163-3864
Projects: KIWIZ, Future Ocean
Date Deposited: 03 Dec 2008 16:52
Last Modified: 04 May 2018 08:44
URI: http://oceanrep.geomar.de/id/eprint/3197

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