Photoswitchable Magnetic Resonance Imaging Contrast by Improved Light-Driven Coordination-Induced Spin State Switch.

Dommaschk, Marcel, Peters, Morten, Gutzeit, Florian, Schuett, Christian, Naether, Christian, Sönnichsen, Frank, Tiwar, Sanjay, Riedel, Christian, Boretius, Susann and Herges, Rainer (2015) Photoswitchable Magnetic Resonance Imaging Contrast by Improved Light-Driven Coordination-Induced Spin State Switch. Journal of the American Chemical Society, 137 (24). pp. 7552-7555. DOI 10.1021/jacs.5b00929.

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Abstract

We present a fully reversible and highly efficient on-off photoswitching of magnetic resonance imaging (MRI) contrast with green (500 nit), and violet-blue (435 nm) light. The contrast change is based on inframolecular light-driven coordination-induced spin state switch (LD-CISSS), performed with azopyridine-substituted Ni-porphyrins. The relaxation time Of the solvent protons in 3 mM solutions of the azoporphyrins in DMSO was switched between 3.5 and 1.7 s. The relaxivity of the contrast agent changes by a factor of 6.7. No fatigue or side reaction was observed, even after >100 000 switching cycles in air at room temperature. Electron-donating substituents at the pyridine improve the LD-CISSS in two ways: better photostationary states are achieved, and intramolecular binding is enhanced.

Document Type: Article
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1021/jacs.5b00929
ISSN: 0002-7863
Projects: Future Ocean
Date Deposited: 20 Oct 2016 10:54
Last Modified: 22 Aug 2019 12:25
URI: http://oceanrep.geomar.de/id/eprint/32454

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