Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance.

Fraune, Sebastian, Anton-Erxleben, Friederike, Augustin, Rene, Franzenburg, Soeren, Knop, Mirjam, Schroeder, Katja, Willoweit-Ohl, Doris and Bosch, Thomas (2015) Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance. Isme Journal, 9 (7). pp. 1543-1556. DOI 10.1038/ismej.2014.239.

Full text not available from this repository.

Supplementary data:

Abstract

Epithelial surfaces of most animals are colonized by diverse microbial communities. Although it is generally agreed that commensal bacteria can serve beneficial functions, the processes involved are poorly understood. Here we report that in the basal metazoan Hydra, ectodermal epithelial cells are covered with a multilayered glycocalyx that provides a habitat for a distinctive microbial community. Removing this epithelial microbiota results in lethal infection by the filamentous fungus Fusarium sp. Restoring the complex microbiota in gnotobiotic polyps prevents pathogen infection. Although mono-associations with distinct members of the microbiota fail to provide full protection, additive and synergistic interactions of commensal bacteria are contributing to full fungal resistance. Our results highlight the importance of resident microbiota diversity as a protective factor against pathogen infections. Besides revealing insights into the in vivo function of commensal microbes in Hydra, our findings indicate that interactions among commensal bacteria are essential to inhibit pathogen infection.

Document Type: Article
Additional Information: Times Cited: 2
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1038/ismej.2014.239
ISSN: 1751-7362
Projects: Future Ocean
Date Deposited: 20 Oct 2016 10:51
Last Modified: 19 Jul 2019 07:45
URI: http://oceanrep.geomar.de/id/eprint/32480

Actions (login required)

View Item View Item