Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.

Lindner, Cornelia, Thomsen, Irene, Wahl, Benjamin, Ugur, Milas, Sethi, Maya K., Friedrichsen, Michaela, Smoczek, Anna, Ott, Stephan, Baumann, Ulrich, Suerbaum, Sebastian, Schreiber, Stefan, Bleich, Andre, Gaboriau-Routhiau, Valerie, Cerf-Bensussan, Nadine, Hazanov, Helena, Mehr, Ramit, Boysen, Preben, Rosenstiel, Philip and Pabst, Oliver (2015) Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nature Immunology, 16 (8). 880-+. DOI 10.1038/ni.3213.

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Supplementary data:

Abstract

Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn.

Document Type: Article
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1038/ni.3213
ISSN: 1529-2908
Projects: Future Ocean
Date Deposited: 18 Oct 2016 03:47
Last Modified: 19 Jul 2019 09:03
URI: http://oceanrep.geomar.de/id/eprint/32574

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