Effects of Dietary Exposure to Zearalenone (ZEN) on Carp (Cyprinus carpio L.).

Pietsch, Constanze, Kersten, Susanne, Valenta, Hana, Daenicke, Sven, Schulz, Carsten, Burkhardt-Holm, Patricia and Junge, Ranka (2015) Effects of Dietary Exposure to Zearalenone (ZEN) on Carp (Cyprinus carpio L.). Toxins, 7 (9). pp. 3465-3480. DOI 10.3390/toxins7093465.

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Supplementary data:

Abstract

The mycotoxin zearalenone (ZEN) is frequently contaminating animal feeds including feed used in aquaculture. In the present study, the effects of dietary exposure to ZEN on carp (Cyprinus carpio L.) were investigated. ZEN at three different concentrations (low dose: 332 mu g kg(-1), medium dose: 621 mu g kg(-1) and high dose: 797 mu g kg(-1) final feed, respectively) was administered to juvenile carp for four weeks. Additional groups received the mycotoxin for the same time period but were fed with the uncontaminated diet for two more weeks to examine the reversibility of the ZEN effects. No effects on growth were observed during the feeding trial, but effects on haematological parameters occurred. In addition, an influence on white blood cell counts was noted whereby granulocytes and monocytes were affected in fish treated with the medium and high dose ZEN diet. In muscle samples, marginal ZEN and -zearalenol (-ZEL) concentrations were detected. Furthermore, the genotoxic potential of ZEN was confirmed by analysing formation of micronuclei in erythrocytes. In contrast to previous reports on other fish species, estrogenic effects measured as vitellogenin concentrations in serum samples were not increased by dietary exposure to ZEN. This is probably due to the fact that ZEN is rapidly metabolized in carp.

Document Type: Article
Additional Information: Times Cited: 1
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
OceanRep > The Future Ocean - Cluster of Excellence > FO-R04
Kiel University
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.3390/toxins7093465
ISSN: 2072-6651
Projects: Future Ocean
Date Deposited: 18 Oct 2016 03:45
Last Modified: 23 Sep 2019 19:16
URI: http://oceanrep.geomar.de/id/eprint/32634

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