The role of linkage disequilibrium in case-only studies of gene-environment interactions.

Yadav, Pankaj, Freitag-Wolf, Sandra, Lieb, Wolfgang and Krawczak, Michael (2015) The role of linkage disequilibrium in case-only studies of gene-environment interactions. Human Genetics, 134 (1). pp. 89-96.

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Abstract

Gene-environment (G x E) interactions have been invoked to account, at least in part, for the gap between the known heritability of common human diseases and the phenotypic variation hitherto explained by genetic variants. Noteworthy in this context, a case-only (CO) design has been proposed in the past as a means to detect G x E interactions possibly more efficiently than by using classical case-control and cohort designs. So far, however, most CO studies have followed a candidate (or single) gene approach, and the genome-wide utility of the CO design is still more or less unknown. In particular, the way in which linkage disequilibrium (LD) impacts upon the chance to detect G x E interaction through the analysis of proxy markers has not been studied in much detail before. Therefore, we systematically assessed the power to indirectly detect a given G x E interaction through exploiting LD in a CO design. Our simulations revealed a strong relationship between LD and detection power that was subsequently validated in a real colorectal cancer data set.

Document Type: Article
Additional Information: Times Cited: 1
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 0340-6717
Projects: Future Ocean
Date Deposited: 18 Oct 2016 03:47
Last Modified: 18 Oct 2016 03:47
URI: http://oceanrep.geomar.de/id/eprint/32765

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