Engyodontochones, Antibiotic Polyketides from the Marine FungusEngyodontium albumStrain LF069.

Wu, Bin, Wiese, Jutta , Wenzel-Storjohann, Arlette, Malien, Susann, Schmaljohann, Rolf and Imhoff, Johannes F. (2016) Engyodontochones, Antibiotic Polyketides from the Marine FungusEngyodontium albumStrain LF069. Chemistry - a European Journal, 22 (22). pp. 7452-7462. DOI 10.1002/chem.201600430.

[img] Text
Wu_et_al-2016-Chemistry_-_A_European_Journal.pdf - Published Version
Restricted to Registered users only

Download (1555Kb) | Contact
[img] Text
chem201600430-sup-0001-misc_information.pdf - Supplemental Material
Restricted to Registered users only

Download (1240Kb) | Contact

Supplementary data:

Abstract

Six new (2, 4–8) and two known polyketides with a basic structure of an anthraquinone-xanthone were isolated from mycelia and culture broth of the fungus Engyodontium album strain LF069. The structures and relative configurations of these compounds were established by spectroscopic means, and their absolute configurations were defined mainly by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Compounds 2 and 4–8 were given the trivial names engyodontochone A (2) and B–F (4–8). Compounds 5–8 represent the first example of a 23,28 seco-beticolin carbon skeleton. The relative and absolute configurations of two known substances JBIR-97/98 (1) and JBIR-99 (3) were determined for the first time. All isolated compounds were subjected to bioactivity assays. Compounds 1–4 exhibited inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) that was 10-fold stronger than chloramphenicol.

Document Type: Article
Additional Information: WOS:000379727900022, PubMed ID: 27098103
Keywords: antibiotics; drug discovery; natural products; polyketides; structure elucidation
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MN Marine natural products chemistry
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
Open Access Journal?: No
DOI etc.: 10.1002/chem.201600430
ISSN: 0947-6539
Related URLs:
Date Deposited: 09 Jun 2016 08:04
Last Modified: 01 Feb 2019 15:14
URI: http://oceanrep.geomar.de/id/eprint/33031

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...