Chromosomal evolution of the PKD1 gene family in primates.

Kirsch, Stefan, Pasantes, Juanjo, Wolf, Andreas, Bogdanova, Nadia, Münch, Claudia, Pennekamp, Petra, Krawczak, Michael, Dworniczak, Bernd and Schempp, Werner (2008) Chromosomal evolution of the PKD1 gene family in primates. Open Access BMC Evolutionary Biology, 8 (1). p. 263. DOI 10.1186/1471-2148-8-263.

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The autosomal dominant polycystic kidney disease (ADPKD) is mostly caused by mutations in the PKD1 (polycystic kidney disease 1) gene located in 16p13.3. Moreover, there are six pseudogenes of PKD1 that are located proximal to the master gene in 16p13.1. In contrast, no pseudogene could be detected in the mouse genome, only a single copy gene on chromosome 17. The question arises how the human situation originated phylogenetically. To address this question we applied comparative FISH-mapping of a human PKD1-containing genomic BAC clone and a PKD1-cDNA clone to chromosomes of a variety of primate species and the dog as a non-primate outgroup species.

Document Type: Article
Keywords: Autosomal Dominant Polycystic Kidney Disease, Common Marmoset, Brown Lemur, Proboscis Monkey, PKD1 Gene
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: 10.1186/1471-2148-8-263
ISSN: 1471-2148
Projects: Future Ocean
Date Deposited: 20 Jun 2016 12:16
Last Modified: 23 Sep 2019 20:44

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