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Early postnatal feed restriction reduces liver connective tissue levels and affects H3K9 acetylation state of regulated genes associated with protein metabolism in low birth weight pigs.
Nebendahl, C., Gors, S., Albrecht, E., Kruger, R., Martens, K., Giller, K., Hammon, H. M., Rimbach, Gerald and Metges, C. C. (2016) Early postnatal feed restriction reduces liver connective tissue levels and affects H3K9 acetylation state of regulated genes associated with protein metabolism in low birth weight pigs. The Journal of Nutritional Biochemistry, 29 . pp. 41-55. DOI 10.1016/j.jnutbio.2015.10.017.
Full text not available from this repository.Abstract
Intrauterine growth retardation is associated with metabolic consequences in adulthood. Since our previous data indicate birth weight-dependent effects of feed restriction (R) on protein degradation processes in the liver, it should be investigated whether effects on connective tissue turnover are obvious and could be explained by global changes of histone H3K9me3 and H3K9ac states in regulated genes. For this purpose, female littermate pigs with low (U) or normal (N) birth weight were subjected to 3-week R (60% of ad libitum fed controls) with subsequent refeeding (REF) for further 5 weeks. The 3-week R-period induced a significant reduction of connective tissue area by 43% in the liver of U animals at 98 d of age, which was not found in age-matched N animals. Of note, after REF at 131 d of age, in previously feed-restricted U animals (UR), the percentage of mean connective tissue was only 53% of ad libitum fed controls (UK), indicating a persistent effect. In U animals, R induced H3K9 acetylation of regulated genes (e.g. XBP1, ERLEC1, GALNT2, PTRH2), which were inter alia associated with protein metabolism. In contrast, REF was mostly accompanied by deacetylation in U and N animals. Thus, our epigenetic data may give a first explanation for the observed birth weight-dependent differences in this connective tissue phenotype. (C) 2015 Elsevier Inc. All rights reserved.
Document Type: | Article |
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Additional Information: | Times Cited: 0 Nebendahl, Constance Goers, Solvig Albrecht, Elke Krueger, Ricarda Martens, Karen Giller, Katrin Hammon, Harald M. Rimbach, Gerald Metges, Cornelia C. |
Keywords: | IUGR, Connective liver tissue, H3K9ac, H3K9me3, Gene expression, Epigenetics |
Research affiliation: | OceanRep > The Future Ocean - Cluster of Excellence Kiel University |
Refereed: | Yes |
Open Access Journal?: | No |
Publisher: | Elsevier |
Projects: | Future Ocean |
Date Deposited: | 27 Feb 2017 08:37 |
Last Modified: | 03 Jun 2019 14:34 |
URI: | https://oceanrep.geomar.de/id/eprint/36231 |
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