The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?.

Seemanova, E., Varon, R., Vejvalka, J., Jarolim, P., Seeman, P., Chrzanowska, K. H., Digweed, M., Resnick, I., Kremensky, I., Saar, K., Hoffmann, K., Dutrannoy, V., Karbasiyan, M., Ghani, M., Baric, I., Tekin, M., Kovacs, P., Krawczak, Michael, Reis, A., Sperling, K. and Nothnagel, M. (2016) The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?. Plos One, 11 (12). DOI http://dx.doi.org/10.1371/journal.pone.0167984.

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Supplementary data:

Abstract

The vast majority of patients with Nijmegen Breakage Syndrome (NBS) are of Slavic origin and carry a deleterious deletion (c.657de15; rs587776650) in the NBN gene on chromosome 8q21. This mutation is essentially confined to Slavic populations and may thus be considered a Slavic founder mutation. Notably, not a single parenthood of a homozygous c.657de15 carrier has been reported to date, while heterozygous carriers do reproduce but have an increased cancer risk. These observations seem to conflict with the considerable carrier frequency of c.657de15 of 0.5% to 1% as observed in different Slavic populations because deleterious mutations would be eliminated quite rapidly by purifying selection. Therefore, we propose that heterozygous c.657de15 carriers have increased reproductive success, i.e., that the mutation confers heterozygote advantage. In fact, in our cohort study of the reproductive history of 24 NBS pedigrees from the Czech Republic, we observed that female carriers gave birth to more children on average than female non-carriers, while no such reproductive differences were observed for males. We also estimate that c.657de15 likely occurred less than 300 generations ago, thus supporting the view that the original mutation predated the historic split and subsequent spread of the 'Slavic people'. We surmise that the higher fertility of female c.657de15 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination, akin to the previously described role of the DNA repair genes BRCA1 and BRCA2.

Document Type: Article
Additional Information: Times Cited: 0 Seemanova, Eva Varon, Raymonda Vejvalka, Jan Jarolim, Petr Seeman, Pavel Chrzanowska, Krystyna H. Digweed, Martin Resnick, Igor Kremensky, Ivo Saar, Kathrin Hoffmann, Katrin Dutrannoy, Veronique Karbasiyan, Mohsen Ghani, Mehdi Baric, Ivo Tekin, Mustafa Kovacs, Peter Krawczak, Michael Reis, Andre Sperling, Karl Nothnagel, Michael
Keywords: Haplotypes Gene mapping Heredity DNA recombination Slavic people Population growth Deletion mutation Miscarriage
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
Open Access Journal?: Yes
DOI etc.: http://dx.doi.org/10.1371/journal.pone.0167984
ISSN: 1932-6203
Projects: Future Ocean
Date Deposited: 17 Mar 2017 07:12
Last Modified: 06 Jun 2019 09:50
URI: http://oceanrep.geomar.de/id/eprint/36314

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